Biocompatible Microemulsions Based on Oleic Acid Modified with Piperidinium Surfactants
نویسندگان
چکیده
Abstract A series of microemulsions based on oleic acid and Tween 80, modified with piperidinium surfactants, have been obtained characterized. The effect additives the size, stability, solubilization formed systems respect to hydrophilic (rhodamine B) hydrophobic (indomethacin) substances investigated. Varying components ratio has allowed preparation strongly different viscosity: from easy-flowing formulations gels. Kinetic parameters describing release substrates obtained. In vivo tests anti-inflammatory action loaded indomethacin shown that presence surfactants enhances therapeutic drug.
منابع مشابه
Physicochemical properties of oleic acid-based partially fluorinated gemini surfactants.
We have developed oleic acid-based partially fluorinated gemini surfactants with carboxylic acid headgroups. The fluorocarbon chain is covalently bound to the terminal carbonyl group of oleic acid via a -CH(2)CH(2)OCO- unit, and the carboxylic acid headgroups are introduced to the cis double bond of oleic acid via -OCOCH(2)CH(2)- units. The aqueous solution properties of these surfactants were ...
متن کاملMicroemulsions with Nonionic Surfactants and Mint Oil
A combination of electrical conductivity, dynamic viscosity, dynamic light scattering and small angle X-ray scattering methods was used to study the properties of the water + propylene glycol/mixed nonionic surfactants/ peppermint oil + ethanol U-type microemulsions which can be diluted with any amount of water. The surfactants were sucrose laurate and ethoxylated mono-di-glyceride. The mixing ...
متن کاملPreparation and Characterization of a Novel Biodegradable Epoxy Resin Modified with Epoxidized Oleic Acid
The goal of this research was to study the curing behavior and biodegradability DER 736 modified with epoxidized oleic acid. In this paper we demonstrate the efficient epoxidation of oleic acid with performic acid generated in situ from formic acid and hydrogen peroxide in the presence of H2SO4 as catalyst. The highest relative epoxy yield of 61% was achieved at 40 ͦC after 10 h. DER 736 modifie...
متن کاملAmino acid-based surfactants
The amino acid-based surfactants contain an amide bond, which may contribute to the selfassembly of the surfactants both at surfaces and in the bulk. In order to assess the importance of this type of intermolecular association, the behavior of sodium lauroyl glycinate and sodium lauroyl sarcosinate were compared. The former surfactant is capable of forming intermolecular hydrogen bonds while th...
متن کاملBiocompatible surfactants for water-in-fluorocarbon emulsions.
Drops of water-in-fluorocarbon emulsions have great potential for compartmentalizing both in vitro and in vivo biological systems; however, surfactants to stabilize such emulsions are scarce. Here we present a novel class of fluorosurfactants that we synthesize by coupling oligomeric perfluorinated polyethers (PFPE) with polyethyleneglycol (PEG). We demonstrate that these block copolymer surfac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Russian Journal of General Chemistry
سال: 2023
ISSN: ['1070-3632', '1608-3350']
DOI: https://doi.org/10.1134/s1070363223030167